Exposure, Dose, Body Burden and Health Effects of Lead

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00013819

Enrollment

944

Registered

2001-03-30

Start date

1997-02-28

Completion date

2001-02-28

Last updated

2015-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lead Poisoning

Keywords

lead poisoning, central nervous system, peripheral nervous system, occupational health, genetic susceptibility

Brief summary

This is a study of the effects that lead has on the health of the central nervous system (for example, memory), peripheral nervous system (for example, sensation and strength in the hands and fingers), kidneys, blood pressure, and the blood forming system. A total of 803 lead workers and 135 persons without occupational lead exposure are being studied in South Korea. Lead in the body is being assessed by measurement of blood lead, chelatable lead (an estimate of lead in the tissues), and lead in bone. Subjects are tested three times each over three years. Several genetic factors are also being assessed for the role they play in the health effects of lead. These genes are known to differ among individuals. We are interested to know whether different forms of the same genes can modify the effect lead has on health.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

17 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Lead workers in South Korea in one of 26 specific lead-using facilities. Population controls in South Korea.

Outcome results