HIV Infections, HIV Seronegativity
Conditions
Keywords
Injections, Intramuscular, Injections, Intradermal, Injections, Subcutaneous, HIV-1, AIDS Vaccines, Dendritic Cells, HIV Seronegativity, Genes, env, Genes, pol, Genes, gag, Transfection, HIV Preventive Vaccine
Brief summary
The purpose of this study is to determine the best way to administer the candidate HIV vaccine, ALVAC HIV-1 (vCP205).
Detailed description
Healthy adult volunteers are assigned randomly to either a vaccine or placebo group. Injections are received either intramuscularly, intradermally, or by delivery under the skin of the volunteer's own white blood cells which have had dendritic cell reinfusion. Volunteers are vaccinated at 0, 1, 3, and 6 month time points. Volunteers are closely monitored for 1 hour after vaccination and keep a diary of symptoms for 1 week post-immunization. Volunteers undergo leukopheresis at the start of the study and after the last vaccination at Walter Reed Army Medical Center. Volunteers receive compensation benefits.
Interventions
BIOLOGICALALVAC-HIV MN120TMG (vCP205)
Sponsors
Walter Reed Army Institute of Research (WRAIR)
Study design
Primary purpose
PREVENTION
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Volunteers may be eligible for this study if they: * Are legal US residents. * Are healthy adults from 18 to 55 years of age.
Exclusion criteria
Volunteers will not be eligible for this study if they: * Are HIV-positive. * Are at highest risk for HIV infection. * Are pregnant or breast-feeding. * Are allergic to eggs or neomycin. * Use certain prescription medications.
Countries
United States
Outcome results
None listed