Protection Against Benzene Toxicity

NQO1 in Protection Against Benzene Toxicity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00011453

Enrollment

Unknown

Registered

2001-02-23

Start date

1998-07-31

Completion date

2001-06-30

Last updated

2005-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aplastic Anemia, Leukemia

Keywords

NQO1, DT-diaphorase, Benzene, Leukemia, Aplastic anemia

Brief summary

We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.

Countries

United States

Outcome results