Lupus Erythematosus, Systemic
Conditions
Brief summary
Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is overexpressed by a subset of white blood cells, called lymphocytes, in patients with lupus. Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus. Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus. We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression.
Interventions
None listed
Sponsors
Arthritis Foundation
National Center for Research Resources (NCRR)
Study design
Observational model
CASE_CONTROL
Eligibility
Sex/Gender
ALL
Age
13 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Inclusion: A diagnosis of systemic lupus erythematosus
Countries
United States
Contacts
Primary ContactRandy Q Cron, MD, Ph.D.
Outcome results
None listed