Decubitus Ulcer
Conditions
Keywords
Analgesia, Bedsore, Morphine gel, Pressure ulcer, Pain, Ulcer
Brief summary
This study tests the effectiveness of a morphine-containing gel for reducing pain caused by pressure ulcers, also known as bedsores or pressure sores. We will apply the gel containing morphine, or the gel alone, directly onto painful pressure ulcers and compare the results.
Detailed description
In this study, we will apply a morphine-containing gel (or placebo) directly onto painful pressure ulcers. We will take participants off of any opioid-containing medications upon entry into the study. This allows us to measure any morphine that may enter into the bloodstream from the topically applied gel. The purpose of this study is to examine the efficacy of the gel for pressure ulcer analgesia, as well as the systemic absorption of morphine from the topically applied gel. We will document the amount of pain medications taken by participants to determine whether the gel decreases the need for these drugs.
Interventions
DRUGPain relief for pressure ulcers
Sponsors
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
University of Kansas
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Presence of a Stage II pressure ulcer. * Pressure ulcer must be painful. * Primary Care physician must approve participation. * Thinking ability must be clear and intact. * Willing to change pain medication to oxycodone.
Exclusion criteria
* Allergy to morphine, oxycodone or intrasite gel. * Use of codeine- or morphine-containing medications. * Use of pain medications for anything other than the pressure ulcer.
Countries
United States
Outcome results
None listed