Osteoporosis
Conditions
Keywords
Vitamin D resistance
Brief summary
Vitamin D deficiency is common in the elderly and contributes to the increased incidence of falls, hip fracture and depression in this population. An unknown number of elderly have vitamin D resistance resulting in a functional vitamin D deficiency state. Because there are no simple procedures or blood tests that identify vitamin D resistance, its prevalence and contribution to disability in the elderly is unknown. Our inability to screen for this condition precludes our ability to initiate and monitor treatment. Previous studies indicate that fingernail thickness correlates with vitamin D status and may therefore provide a simple cost effective procedure to not only identify patients with vitamin D deficiency but also, those with vitamin D resistance. This procedure may also provide a way to monitor an individual's response to treatment. This study is designed to demonstrate the association between fingernail thickness and vitamin D status.
Interventions
DRUGVitamin D
Sponsors
National Center for Research Resources (NCRR)
Study design
Allocation
RANDOMIZED
Primary purpose
DIAGNOSTIC
Masking
DOUBLE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* females 25-75 years of age with no known bone disorders
Exclusion criteria
* history of vertebral fractures or nonvertebral fractures without trauma * prescription medications for prevention of osteoporosis (including vitamin D other than multivitamin and estrogen) * history of malignancy other than basal cell or squamous cell cancer of the skin * use of steroids or anticonvulsants in the 6 months prior to enrollment
Countries
United States
Outcome results
None listed