Diabetes Mellitus, Type 2, Glucose Intolerance
Conditions
Keywords
low fat diet, aerobic exercise, impaired glucose tolerance, Japanese Americans, metabolic risk factors
Brief summary
Type 2 diabetes is more frequent in Japanese Americans than in Japan or the U.S. non-Hispanic white population. This appears to be due to the effects of ''westernization'' to bring out metabolic changes that lead to diabetes. This study will look at whether increased physical activity and dietary changes will reduce or prevent the metabolic changes that lead to type 2 diabetes in Japanese Americans who have impaired glucose tolerance, a condition intermediate between normal glucose tolerance and diabetes.
Interventions
BEHAVIORALexercise and diet
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Allocation
RANDOMIZED
Primary purpose
PREVENTION
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Japanese American * Confirmed impaired glucose tolerance * Able to fill out questionnaires
Exclusion criteria
* Significant exercise-restricting disease * Poorly controlled hypertension * Psychiatric disease or dementia * Already on unusually restrictive diet * Use of hypolipidemic drugs * Use of tobacco * Abnormal blood screening tests * ECG evidence of ischemic heart disease at rest * Abnormal maximal Bruce treadmill test
Countries
United States
Outcome results
None listed