Esophageal and Gastric Varices, Liver Cirrhosis
Conditions
Keywords
TIPS, DSRS, Varices, Variceal bleeding, Splenorenal Shunt, Transjugular Intrahepatic Portosystemic Shunt, Cirrhosis, Portal hypertension, Liver disease
Brief summary
The Decompression Intervention of Variceal Rebleeding Trial (DIVERT) is a multi-center prospective randomized clinical trial comparing the radiologic procedure of transjugular intrahepatic portal-systemic shunt (TIPS) with the surgical procedure of distal splenorenal shunt (DSRS) for variceal bleeding in patients with Child's Class A and B cirrhosis. This is recognized nationally and internationally as the study that will answer the question as to which of these is the best treatment for decompression of varices in patients who have failed endoscopic and pharmacologic therapy.
Interventions
PROCEDUREDistal Splenorenal Shunt
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Variceal bleeding secondary to cirrhosis and portal hypertension * Child's Class A or B cirrhosis of any etiology * Patients who have failed endoscopic therapy (sclerotherapy or banding) of varices; or patients who are not candidates for endoscopic therapy
Exclusion criteria
* Prior shunt procedure * Portal vein thrombosis * Polycystic liver disease * Intractable ascites * Prior organ transplant * Any medical intractable disease
Countries
United States
Outcome results
None listed