Epidemiology of Sleep-Disordered Breathing in Adults

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00005557

Enrollment

1545

Registered

2000-05-26

Start date

1999-04-30

Completion date

2031-04-30

Last updated

2025-10-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Disease, Cerebrovascular Disorders, Mood Disorders, Neurologic Disorders, Sleep Disorders

Brief summary

To characterize the natural history and biologic spectrum of sleep disordered breathing (SDB) and other sleep problems and disorders, and test hypotheses regarding the causes and consequences of SDB and other sleep problems and disorders.

Detailed description

BACKGROUND: Recent research has shown that sleep disordered breathing (SDB) is much more common than previously thought. While it is known that in clinic samples, SDB is associated with hypertension, cardiovascular disease and mortality, little is known about the natural history of this disorder, particularly in the general population, nor about the causal role of known risk factors. The knowledge obtained from the results of this study will help advance the field of sleep disorders medicine. Information about longitudinal effects and causal relationships may be applied to clinical situations, thus reducing the morbidity and mortality associated with this disorder. DESIGN NARRATIVE: In this longitudinal study, follow-up polysomnography and other protocols are conducted on an established cohort of men and women (age 30-60 years at the time of initial recruitment in 1989), currently enrolled in the Wisconsin Sleep Cohort Study. The study aims to : 1) describe the natural history of SDB across middle and older age; 2) investigate associations of SDB with early and intermediate markers of cardiovascular dysfunction, damage, and cardiovascular disease; 3) investigate the longitudinal association of SDB in accelerated cognitive decline; 4) investigate the association of SDB and adverse sleep characteristics with age-related risk factors and outcomes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 95 Years

Healthy volunteers

Yes

Inclusion criteria

* Employee of one of the 4 Wisconsin state agencies * Age 30-60 in 1988

Exclusion criteria

* Current pregnancy * Unstable or decompensated cardiopulmonary disease * Airway cancer * Recent upper respiratory surgery

Design outcomes

Primary

Measure	Time frame	Description
sleep disorders and problems, cardiovascular and cognitive outcomes	measured at each study visit	Overnight polysomnography is used to assess sleep pathology. Questionnaires are used to assess sleep habits. A variety of clinical and laboratory assessments measure cardiovascular and cognitive outcomes.

Secondary

Measure	Time frame	Description
cardiovascular outcomes	measured at each study visit	A variety of clinical and laboratory assessments measure cardiovascular outcomes.

Other

Measure	Time frame	Description
cognitive outcomes	measured at each study visit	A variety of clinical and laboratory assessments measure cognitive outcomes.
gait and balance	measured at each study visit	A series of walking tests are conducted.
mental health outcomes	evaluated at each study visit	Questionnaires assess mood, depression, and anxiety.

Countries

United States

Outcome results