Linkage Study of Long QT Syndrome In An Amish Kindred

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00005250

Enrollment

Unknown

Registered

2000-05-26

Start date

1990-01-31

Completion date

1992-12-31

Last updated

2016-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases, Heart Diseases, Long QT Syndrome, Tachycardia, Ventricular, Ventricular Fibrillation

Brief summary

To screen by electrocardiography the entire population of 1,400 individuals in seven Amish Mennonite communities in order to perform genetic linkage studies of long QT syndrome (LQTS).

Detailed description

BACKGROUND: LQTS is a severe heart disorder leading to sudden death due to ventricular tachycardia or ventricular fibrillation. The syndrome segregated as a Mendelian recessive in the highly inbred population under study and resulted in the sudden death of several members of the population. DESIGN NARRATIVE: The entire population was screened to identify cases of LQTS. In addition, 29 obligate heterozygotes were studied by 24-hour Holter monitoring to determine whether these gene carriers had any subtle phenotypes. The data were subjected to complex segregation and linkage analysis to establish the mode of inheritance and penetrance of LQTS. The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System (PRS) record.

Interventions

None listed

Eligibility

Sex/Gender

MALE

Age

No minimum to 100 Years

Healthy volunteers

Inclusion criteria

No eligibility criteria

Outcome results