Longitudinal and Biological Study of Childhood Disintegrative Disorder

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00004458

Enrollment

220

Registered

1999-10-19

Start date

1997-05-31

Completion date

Unknown

Last updated

2005-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism, Pervasive Child Development Disorders

Keywords

autism, childhood disintegrative disorder, neurologic and psychiatric disorders, rare disease

Brief summary

OBJECTIVES: I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays. II. Collect data on molecular genetics of proband and family members.

Detailed description

PROTOCOL OUTLINE: Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

Interventions

None listed

Study design

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

2 Years to 9 Years

Healthy volunteers

Inclusion criteria

* Psychologically diagnosed (DSM-IV) as Childhood Disintegrative Disorder * No known genetic or medical syndrome (Down syndrome or cerebral palsy) * Must speak English

Countries

United States

Outcome results