Study of Pituitary Size and Function in Familial Dwarfism of Sindh

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00004365

Enrollment

Registered

1999-10-19

Start date

1995-09-30

Completion date

2000-02-29

Last updated

2005-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Growth Hormone Deficiency

Keywords

endocrine disorders, growth hormone deficiency, rare disease

Brief summary

OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan. II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.

Detailed description

PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated. All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

10 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Familial Dwarfism of Sindh * Severe short stature but proportionate without dysmorphic features * Normal body size and weight at birth * Bone age is severely delayed * Puberty is somewhat delayed (age 15-16) * Fertility present in at least 3 dwarfs

Outcome results