Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00004353

Enrollment

Registered

1999-10-19

Start date

1978-12-31

Completion date

Unknown

Last updated

2008-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lactic Acidosis, MELAS Syndrome, Mitochondrial Myopathy

Keywords

MELAS syndrome, inborn errors of metabolism, lactic acidosis, mitochondrial myopathy, rare disease

Brief summary

OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia. II. Define the nature of the metabolic defect.

Detailed description

PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes. In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points. Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

PROTOCOL ENTRY CRITERIA: * Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients

Countries

United States

Outcome results