Study of the Neurobiology of Tourette Syndrome and Related Disorders

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00004325

Enrollment

200

Registered

1999-10-19

Start date

1988-12-31

Completion date

Unknown

Last updated

2005-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive Compulsive Disorder, Tourette Syndrome

Keywords

Tourette syndrome, anxiety disorder, disease-related problem/condition, neurologic and psychiatric disorders, obsessive compulsive disorder, oncologic disorders, rare disease

Brief summary

OBJECTIVES: I. Investigate the pathobiology of Tourette syndrome and related disorders by measuring various compounds of interest in cerebrospinal fluid, plasma, and urine of patients with Tourette syndrome, obsessive compulsive disorder, and/or chronic tics. II. Determine the pattern of familial aggregation of Tourette syndrome and obsessive compulsive disorder by systematic assessment of all first-degree family members of patients selected for cerebrospinal fluid studies. III. Establish the neurochemical and neuropeptide profile associated with the range of expression of the putative Tourette gene expression in adult and adolescent patients.

Detailed description

PROTOCOL OUTLINE: All patients are screened with a complete physical and neurologic exam, and a semi-structured interview. Patients then receive a comprehensive assessment of systemic disease. Patients and first-degree family members also participate in a genetic study. Any patient who experiences an unusual exacerbation of symptoms or significant side effects is removed from the study.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

12 Years to 45 Years

Healthy volunteers

Inclusion criteria

PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Diagnostic and Statistical Manual of Mental Disorders IV lifetime diagnosis of 1 or more of the following: * Tourette syndrome (TS) * Obsessive compulsive disorder * Chronic tics Severely affected adolescents with a score of 3 or greater on the TS-Clinical Global Impression Scale eligible --Prior/Concurrent Therapy-- At least 1 month since any medication --Patient Characteristics-- Other: * In good physical health * No alcohol or substance abuse * No Intelligence Quotient below 80 * Negative pregnancy test required of fertile women

Countries

United States

Outcome results