Atypical Mycobacterium Infection, Cystic Fibrosis
Conditions
Keywords
atypical mycobacterium infection, bacterial infection, cardiovascular and respiratory diseases, cystic fibrosis, genetic diseases and dysmorphic syndromes, immunologic disorders and infectious disorders, mycobacterium infection, rare disease
Brief summary
OBJECTIVES: I. Determine the prevalence of nontuberculous mycobacteria in sputum cultures from patients with cystic fibrosis. II. Compare the clinical course of patients with negative versus positive cultures.
Detailed description
PROTOCOL OUTLINE: Participants are screened for nontuberculous mycobacteria (NTM) with 3 sputum acid-fast bacilli smears and mycobacterial cultures, with speciation of positive cultures, collected over 1 year. Demographic data, diagnostic criteria, clinical measurements, and other respiratory pathogen data are collected using the Cystic Fibrosis Foundation Patient Registry Questionnaire. NTM-positive patients (cases) matched with NTM-negative controls identified in screening are followed every 3 months for 15 months. Cases are evaluated for NTM burden during the first 3 months. Appropriate therapy is offered to consistently NTM-positive cases. Lung transplant recipients are removed from study.
Interventions
None listed
Sponsors
University of North Carolina
National Center for Research Resources (NCRR)
Study design
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
10 Years to No maximum
Healthy volunteers
No
Inclusion criteria
PROTOCOL ENTRY CRITERIA: Patients over age 10 with cystic fibrosis documented as follows: * Pilocarpine sweat chloride test at least 60 mEq/L OR * Genotyping or transepithelial potential difference AND * Clinical symptoms of suppurative respiratory disease or pancreatic insufficiency Able to produce at least 3 sputum samples * Bronchoscopy specimens acceptable * Throat/nasal specimens not acceptable No Pseudomonas cepacia colonization
Outcome results
None listed