Turner's Syndrome
Conditions
Keywords
Turner's syndrome, genetic diseases and dysmorphic syndromes, rare disease
Brief summary
RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome. Estrogen may be effective treatment for mental and social functioning problems experienced by girls with Turner's syndrome. PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome.
Detailed description
PROTOCOL OUTLINE: Participants are evaluated for cognitive and social function at entry and 4 years following entry. Assessments include the Wechsler Intelligence Scale for Children-Revised, a child behavior checklist, the Children's Self-Concept Scale, and visual-spatial, visual-motor, attention, memory, language, and facial recognition tasks. Patients (and parents) undergo X-chromosome analysis; brain magnetic imaging is optional. Controls are matched using school selection and telephone interviews. A study duration of 12 years is estimated.
Interventions
DRUGEstrogen
Sponsors
Jefferson Medical College of Thomas Jefferson University
National Institute of Neurological Disorders and Stroke (NINDS)
Study design
Primary purpose
TREATMENT
Eligibility
Sex/Gender
FEMALE
Age
8 Years to 12 Years
Healthy volunteers
Yes
Inclusion criteria
PROTOCOL ENTRY CRITERIA: * Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype * Age-matched girls without Turner's syndrome entered as controls * Concurrent registration on Thomas Jefferson University growth study required of subjects with Turner's syndrome
Countries
United States
Outcome results
None listed