Multiple Myeloma and Plasma Cell Neoplasm
Conditions
Keywords
stage I multiple myeloma, stage II multiple myeloma, stage III multiple myeloma
Brief summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow doctors to give higher doses of chemotherapy drugs and kill more cancer cells. Biological therapies, such as interferon alfa, use different ways to stimulate the immune system and stop cancer cells from growing. Thalidomide may stop the growth of cancer cells by stopping blood flow to the tumor. Pamidronate may help to reduce the side effects of treatment for multiple myeloma. PURPOSE: This phase II trial is studying combination chemotherapy, peripheral stem cell transplantation, biological therapy, pamidronate, and thalidomide to see how well they work in treating patients with stage I, stage II, or stage III multiple myeloma.
Detailed description
OBJECTIVES: * Determine the feasibility and toxic effects of high-dose melphalan, busulfan, and cyclophosphamide followed by autologous peripheral blood stem cell rescue, interferon alfa, and pamidronate in patients with responsive or stable, low-bulk multiple myeloma. * Determine the response rate and progression-free and overall survival of patients treated with this regimen. * Determine the feasibility of adding thalidomide to interferon alfa and pamidronate in patients who are not in complete remission (CR) 6 months after the second course of high-dose chemotherapy. * Determine whether administration of thalidomide can increase the CR rate in patients who are not in CR 6 months after the second course of high-dose chemotherapy and determine its effect on progression-free and overall survival of these patients. * Determine the pharmacokinetics of busulfan and cyclophosphamide and correlate the pharmacokinetics with the toxic effects of these drugs and outcome in these patients. * Determine the effect of thalidomide on microvascular density of bone marrow and correlate these possible effects with outcome in these patients. * Determine the cytogenetics, gene rearrangement, and fluorescence in situ hybridization in baseline and post treatment bone marrow and blood specimens and correlate the presence/persistence of these features with treatment outcome in these patients. OUTLINE: Patients receive cyclophosphamide IV over 2 hours on day 1 and filgrastim (G-CSF) subcutaneously (SC) or IV twice a day beginning on day 2 and continuing until peripheral blood stem cells (PBSCs) are collected. PBSCs are collected beginning on day 10. Patients receive high-dose melphalan IV on day -1. PBSCs are reinfused on day 0. G-CSF is administered IV or SC daily beginning on day 1 and continuing until blood counts recover. Between 8 and 14 weeks later, patients receive high-dose busulfan IV every 6 hours on days -7 to -4 and cyclophosphamide IV over 2 hours on days -3 and -2. PBSCs are reinfused on day 0 and G-CSF is administered IV or SC daily until blood counts recover. Patients with responding or stable disease after chemotherapy receive maintenance therapy with interferon alfa beginning 14-20 weeks after day 0 of the second course of chemotherapy. Interferon alfa is administered SC 3 times a week for 3 years. Patients also receive pamidronate IV every 4 weeks until disease progression. Patients who are not in complete remission (CR) 6 months after completing the second course of chemotherapy receive oral thalidomide daily for a maximum of 1 year or for 3 months after achieving CR. Patients are followed monthly for 1 year, every 3 months for 1 year, and then periodically thereafter. PROJECTED ACCRUAL: A total of 70 patients will be accrued for this study within approximately 2.5 years.
Interventions
BIOLOGICALfilgrastim
BIOLOGICALrecombinant interferon alfa
DRUGbusulfan
DRUGcyclophosphamide
DRUGmelphalan
DRUGthalidomide
PROCEDUREperipheral blood stem cell transplantation
Sponsors
National Cancer Institute (NCI)
City of Hope Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 65 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histologically proven stage I-III multiple myeloma * Less than 18 months since diagnosis * Smoldering myeloma allowed if there is evidence of progressive disease requiring therapy * At least 25% increase in M protein levels or Bence Jones excretion * Hemoglobin no greater than 10.5 g/dL * Hypercalcemia * Frequent infections * Rise in serum creatinine above normal on 2 separate occasions * Nonquantifiable monoclonal proteins allowed if other criteria for multiple myeloma or smoldering myeloma are met * Response/status after induction therapy: * Responding or stable disease AND no greater than 40% myelomatous involvement of bone marrow * No Waldenstrom's macroglobulinemia PATIENT CHARACTERISTICS: Age: * 65 and under Performance status: * Karnofsky 80-100% Life expectancy: * Not specified Hematopoietic: * See Disease Characteristics * Absolute neutrophil count greater than 1,500/mm\^3 * Platelet count greater than 100,000/mm\^3 Hepatic: * Bilirubin no greater than 1.5 mg/dL * Serum glutamic axaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) less than 2.5 times upper limit of normal * Hepatitis B antigen or hepatitis C ribonucleaic acid (RNA) negative Renal: * See Disease Characteristics * Creatinine no greater than 1.4 mg/dL * Creatinine clearance greater than 65 mL/min Cardiovascular: * Cardiac ejection fraction at least 50% by multigated acquisition scan (MUGA) or echocardiogram Pulmonary: * Forced-expiratory volume in one second (FEV\_1) greater than 60% of normal * Diffusing capacity for carbon monoxide (DLCO) greater than 50% of predicted lower limit Other: * Not pregnant * Negative pregnancy test * Fertile patients must use effective contraception * Human immunodeficiency virus (HIV) negative * No other medical or psychosocial problems that would increase patient risk * No other malignancy within past 5 years except nonmelanomatous skin cancer or carcinoma in situ of the cervix * No known hypersensitivity to filgrastim (G-CSF) or Escherechi coli-derived proteins PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * See Disease Characteristics * No more than 3 prior chemotherapy regimens * At least 4 weeks since prior chemotherapy Endocrine therapy: * Not specified Radiotherapy: * At least 4 weeks since prior radiotherapy Surgery: * Not specified
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Best Response Prior to Tandem Autologous Stem Cell Transplant | From enrollment in the study until day -8: before dilantin given pre-first high-dose chemo preceeding first cycle of tandem autologous cell transplant | Response gradations are specified in the Blade criteria, Br J Haematol 1998; 102: 1115-1123. Serum myeloma protein is measured 2x at least six weeks apart, and urine M-component is measured 2x at least 3 weeks apart. Complete response (CR): less than 3% plasma cells in bone marrow or blood. Very good partial response (VGPR): Greater than 90% decrease in myeloma protein, and urine M-component less than 0.1 gm/day. Partial response (PR) Greater than 50% decrease in myeloma protein; urine M-component less than 0.2 gm/day. Lytic skeletal lesions must not increase, and serum calcium level must remain normal. Stable disease (SD): 25-49% decrease in protein and 25% decrease in urine M-component. Progressive disease (PD): Greater than 25% increase in myeloma protein, or hypercalcemia. Relapse: 1) increase greater than 100% of myeloma protein; 2) More than 25% increase of myeloma protein; 3) reappearance of the myeloma peaks; 4) increase in lytic bone lesions on radiographs. |
| Response After Tandem Autologous Stem Cell Transplant | After second cycle of tandem autologous stem cell transplant: Day 0 of second transplant to 12 weeks post-cycle 2 cell infusion of the tandem transplant. | Response gradations are specified in the Blade criteria, Br J Haematol 1998; 102: 1115-1123. Serum myeloma protein is measured 2x at least six weeks apart, and urine M-component is measured 2x at least 3 weeks apart. Complete response (CR): less than 3% plasma cells in bone marrow or blood. Very good partial response (VGPR): Greater than 90% decrease in myeloma protein, and urine M-component less than 0.1 gm/day. Partial response (PR) Greater than 50% decrease in myeloma protein; urine M-component less than 0.2 gm/day. Lytic skeletal lesions must not increase, and serum calcium level must remain normal. Stable disease (SD): 25-49% decrease in protein and 25% decrease in urine M-component. Progressive disease (PD): Greater than 25% increase in myeloma protein, or hypercalcemia. Relapse: 1) increase greater than 100% of myeloma protein; 2) More than 25% increase of myeloma protein; 3) reappearance of the myeloma peaks; 4) increase in lytic bone lesions on radiographs. |
| Three-year Overall Survival | Estimate reported at three years after day 0 of the first cycle of infusion of cells of the tandem transplant. | Kaplan-Meier estimate at three years post-first transplant of survival. Outcome is death or alive at follow-up (censored). 95 percent confidence interval of the point estimate is calculated using Greenwood's variance. |
| Progression-free Survival | Estimate reported at three years after day 0 of the first cycle of infusion of cells of the tandem transplant. | Kaplan-Meier estimate at three years post-first transplant of survival. Event of interest is the first of Death or Progression. Censoring is Alive in Continuous Complete Remission at date of last follow-up. 95 percent confidence interval of the point estimate is calculated using Greenwood's variance. |
| Best Response at 6 Months Post Tandem Autologous Stem Cell Transplant | Six months after day 0 of the first cycle of the tandem autologous stem cell transplant. This will be used to determine administration of thalidomide. | Response gradations are specified in the Blade criteria, Br J Haematol 1998; 102: 1115-1123. Serum myeloma protein is measured 2x at least six weeks apart, and urine M-component is measured 2x at least 3 weeks apart. Complete response (CR): less than 3% plasma cells in bone marrow or blood. Very good partial response (VGPR): Greater than 90% decrease in myeloma protein, and urine M-component less than 0.1 gm/day. Partial response (PR) Greater than 50% decrease in myeloma protein; urine M-component less than 0.2 gm/day. Lytic skeletal lesions must not increase, and serum calcium level must remain normal. Stable disease (SD): 25-49% decrease in protein and 25% decrease in urine M-component. Progressive disease (PD): Greater than 25% increase in myeloma protein, or hypercalcemia. Relapse: 1) increase greater than 100% of myeloma protein; 2) More than 25% increase of myeloma protein; 3) reappearance of the myeloma peaks; 4) increase in lytic bone lesions on radiographs. |
| Best Response After Tandem Autologous Stem Cell Transplant and Maintenance | Response after six months after day 0 of the first cycle of the tandem transplant, after administration of maintenance thalidomide if necessary, until three years post-day 0 of the first cycle of the tandem transplant. | Response gradations are specified in the Blade criteria, Br J Haematol 1998; 102: 1115-1123. Serum myeloma protein is measured 2x at least six weeks apart, and urine M-component is measured 2x at least 3 weeks apart. Complete response (CR): less than 3% plasma cells in bone marrow or blood. Very good partial response (VGPR): Greater than 90% decrease in myeloma protein, and urine M-component less than 0.1 gm/day. Partial response (PR) Greater than 50% decrease in myeloma protein; urine M-component less than 0.2 gm/day. Lytic skeletal lesions must not increase, and serum calcium level must remain normal. Stable disease (SD): 25-49% decrease in protein and 25% decrease in urine M-component. Progressive disease (PD): Greater than 25% increase in myeloma protein, or hypercalcemia. Relapse: 1) increase greater than 100% of myeloma protein; 2) More than 25% increase of myeloma protein; 3) reappearance of the myeloma peaks; 4) increase in lytic bone lesions on radiographs. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| HD Chemo Followed by PBPC Rescue HD Melphalan/Cyclophosphamide followed by PBPC Rescue, alpha-interferon, & pamidronate | 77 |
| Total | 77 |
Withdrawals & dropouts
| Period | Reason | FG000 |
|---|---|---|
| Overall Study | No C2 given due to study on hold by IRB | 4 |
| Overall Study | Physician Decision | 1 |
| Overall Study | Protocol Violation | 3 |
| Overall Study | Withdrawal by Subject | 1 |
Baseline characteristics
| Characteristic | HD Chemo Followed by PBPC Rescue |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 2 Participants |
| Age, Categorical Between 18 and 65 years | 75 Participants |
| Age, Continuous | 54 years |
| Ethnicity (NIH/OMB) Hispanic or Latino | 5 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 72 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| M protein type IgA | 22 Participants |
| M protein type IgG | 36 Participants |
| M protein type unrecorded | 19 Participants |
| Prior Anthracycline Chemotherapy No | 6 Participants |
| Prior Anthracycline Chemotherapy not recorded | 9 Participants |
| Prior Anthracycline Chemotherapy Yes | 62 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 1 Participants |
| Race (NIH/OMB) Black or African American | 7 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 69 Participants |
| Region of Enrollment United States | 77 participants |
| Sex: Female, Male Female | 27 Participants |
| Sex: Female, Male Male | 50 Participants |
| Stage of Multiple Myeloma Stage III (High Tumor Mass) | 50 Participants |
| Stage of Multiple Myeloma Stage II (Intermediate Tumor Mass) | 12 Participants |
| Stage of Multiple Myeloma Stage I (Low Tumor Mass) | 6 Participants |
| Stage of Multiple Myeloma unrecorded | 9 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 23 / 68 |
| other Total, other adverse events | 68 / 68 |
| serious Total, serious adverse events | 0 / 68 |
Outcome results
Primary
Best Response After Tandem Autologous Stem Cell Transplant and Maintenance
Response gradations are specified in the Blade criteria, Br J Haematol 1998; 102: 1115-1123. Serum myeloma protein is measured 2x at least six weeks apart, and urine M-component is measured 2x at least 3 weeks apart. Complete response (CR): less than 3% plasma cells in bone marrow or blood. Very good partial response (VGPR): Greater than 90% decrease in myeloma protein, and urine M-component less than 0.1 gm/day. Partial response (PR) Greater than 50% decrease in myeloma protein; urine M-component less than 0.2 gm/day. Lytic skeletal lesions must not increase, and serum calcium level must remain normal. Stable disease (SD): 25-49% decrease in protein and 25% decrease in urine M-component. Progressive disease (PD): Greater than 25% increase in myeloma protein, or hypercalcemia. Relapse: 1) increase greater than 100% of myeloma protein; 2) More than 25% increase of myeloma protein; 3) reappearance of the myeloma peaks; 4) increase in lytic bone lesions on radiographs.
Time frame: Response after six months after day 0 of the first cycle of the tandem transplant, after administration of maintenance thalidomide if necessary, until three years post-day 0 of the first cycle of the tandem transplant.
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| HD Chemo Followed by PBPC Rescue | Best Response After Tandem Autologous Stem Cell Transplant and Maintenance | CR | 3 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response After Tandem Autologous Stem Cell Transplant and Maintenance | VGPR | 1 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response After Tandem Autologous Stem Cell Transplant and Maintenance | PR/SD | 6 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response After Tandem Autologous Stem Cell Transplant and Maintenance | PD | 6 Participants |
Primary
Best Response at 6 Months Post Tandem Autologous Stem Cell Transplant
Response gradations are specified in the Blade criteria, Br J Haematol 1998; 102: 1115-1123. Serum myeloma protein is measured 2x at least six weeks apart, and urine M-component is measured 2x at least 3 weeks apart. Complete response (CR): less than 3% plasma cells in bone marrow or blood. Very good partial response (VGPR): Greater than 90% decrease in myeloma protein, and urine M-component less than 0.1 gm/day. Partial response (PR) Greater than 50% decrease in myeloma protein; urine M-component less than 0.2 gm/day. Lytic skeletal lesions must not increase, and serum calcium level must remain normal. Stable disease (SD): 25-49% decrease in protein and 25% decrease in urine M-component. Progressive disease (PD): Greater than 25% increase in myeloma protein, or hypercalcemia. Relapse: 1) increase greater than 100% of myeloma protein; 2) More than 25% increase of myeloma protein; 3) reappearance of the myeloma peaks; 4) increase in lytic bone lesions on radiographs.
Time frame: Six months after day 0 of the first cycle of the tandem autologous stem cell transplant. This will be used to determine administration of thalidomide.
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| HD Chemo Followed by PBPC Rescue | Best Response at 6 Months Post Tandem Autologous Stem Cell Transplant | CR | 18 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response at 6 Months Post Tandem Autologous Stem Cell Transplant | VGPR | 5 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response at 6 Months Post Tandem Autologous Stem Cell Transplant | PR/SD | 29 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response at 6 Months Post Tandem Autologous Stem Cell Transplant | PD | 11 Participants |
Primary
Best Response Prior to Tandem Autologous Stem Cell Transplant
Response gradations are specified in the Blade criteria, Br J Haematol 1998; 102: 1115-1123. Serum myeloma protein is measured 2x at least six weeks apart, and urine M-component is measured 2x at least 3 weeks apart. Complete response (CR): less than 3% plasma cells in bone marrow or blood. Very good partial response (VGPR): Greater than 90% decrease in myeloma protein, and urine M-component less than 0.1 gm/day. Partial response (PR) Greater than 50% decrease in myeloma protein; urine M-component less than 0.2 gm/day. Lytic skeletal lesions must not increase, and serum calcium level must remain normal. Stable disease (SD): 25-49% decrease in protein and 25% decrease in urine M-component. Progressive disease (PD): Greater than 25% increase in myeloma protein, or hypercalcemia. Relapse: 1) increase greater than 100% of myeloma protein; 2) More than 25% increase of myeloma protein; 3) reappearance of the myeloma peaks; 4) increase in lytic bone lesions on radiographs.
Time frame: From enrollment in the study until day -8: before dilantin given pre-first high-dose chemo preceeding first cycle of tandem autologous cell transplant
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| HD Chemo Followed by PBPC Rescue | Best Response Prior to Tandem Autologous Stem Cell Transplant | CR | 1 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response Prior to Tandem Autologous Stem Cell Transplant | VGPR | 4 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response Prior to Tandem Autologous Stem Cell Transplant | PR/SD | 62 Participants |
| HD Chemo Followed by PBPC Rescue | Best Response Prior to Tandem Autologous Stem Cell Transplant | PD | 1 Participants |
Primary
Progression-free Survival
Kaplan-Meier estimate at three years post-first transplant of survival. Event of interest is the first of Death or Progression. Censoring is Alive in Continuous Complete Remission at date of last follow-up. 95 percent confidence interval of the point estimate is calculated using Greenwood's variance.
Time frame: Estimate reported at three years after day 0 of the first cycle of infusion of cells of the tandem transplant.
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| HD Chemo Followed by PBPC Rescue | Progression-free Survival | 0.456 proportion of participants |
Primary
Response After Tandem Autologous Stem Cell Transplant
Response gradations are specified in the Blade criteria, Br J Haematol 1998; 102: 1115-1123. Serum myeloma protein is measured 2x at least six weeks apart, and urine M-component is measured 2x at least 3 weeks apart. Complete response (CR): less than 3% plasma cells in bone marrow or blood. Very good partial response (VGPR): Greater than 90% decrease in myeloma protein, and urine M-component less than 0.1 gm/day. Partial response (PR) Greater than 50% decrease in myeloma protein; urine M-component less than 0.2 gm/day. Lytic skeletal lesions must not increase, and serum calcium level must remain normal. Stable disease (SD): 25-49% decrease in protein and 25% decrease in urine M-component. Progressive disease (PD): Greater than 25% increase in myeloma protein, or hypercalcemia. Relapse: 1) increase greater than 100% of myeloma protein; 2) More than 25% increase of myeloma protein; 3) reappearance of the myeloma peaks; 4) increase in lytic bone lesions on radiographs.
Time frame: After second cycle of tandem autologous stem cell transplant: Day 0 of second transplant to 12 weeks post-cycle 2 cell infusion of the tandem transplant.
| Arm | Measure | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| HD Chemo Followed by PBPC Rescue | Response After Tandem Autologous Stem Cell Transplant | CR | 27 Participants |
| HD Chemo Followed by PBPC Rescue | Response After Tandem Autologous Stem Cell Transplant | VGPR | 11 Participants |
| HD Chemo Followed by PBPC Rescue | Response After Tandem Autologous Stem Cell Transplant | PR/SD | 24 Participants |
| HD Chemo Followed by PBPC Rescue | Response After Tandem Autologous Stem Cell Transplant | PD | 3 Participants |
Primary
Three-year Overall Survival
Kaplan-Meier estimate at three years post-first transplant of survival. Outcome is death or alive at follow-up (censored). 95 percent confidence interval of the point estimate is calculated using Greenwood's variance.
Time frame: Estimate reported at three years after day 0 of the first cycle of infusion of cells of the tandem transplant.
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| HD Chemo Followed by PBPC Rescue | Three-year Overall Survival | 0.662 proportion of participants |