Leukemia
Conditions
Keywords
recurrent adult acute myeloid leukemia, adult acute myeloid leukemia in remission
Brief summary
RATIONALE: Diagnostic procedures, such as genetic testing, may improve the ability to detect acute myeloid leukemia and determine the extent of disease. PURPOSE: Diagnostic study to try to detect changes in the genes of patients who have acute myeloid leukemia.
Detailed description
OBJECTIVES: * Determine the frequency of partial tandem duplication of ALL1 (MLL) in patients with acute myeloid leukemia (AML). * Determine the predictive value of partial tandem duplication of ALL1 to identify a subset of AML patients who have a short duration of complete remission. OUTLINE: All samples are obtained from specimens collected on CALGB-9665. No additional blood or bone marrow samples are collected. Samples are examined by Southern blot analysis for gene rearrangement at 11q23. Samples showing evidence of ALL1 gene rearrangement are further analyzed by reverse transcription PCR amplification and/or cytogenetic analysis to detect partial tandem duplication of ALL1.
Interventions
GENETICreverse transcriptase-polymerase chain reaction
Sponsors
National Cancer Institute (NCI)
Alliance for Clinical Trials in Oncology
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Prior registration on protocol CALGB-9665 * Diagnosed with acute myeloid leukemia (AML) * Treated on a CALGB AML treatment protocol * Diagnostic bone marrow or blood specimen available PATIENT CHARACTERISTICS: Age: * 15 and over
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| frequency of partial tandem duplication of ALL1 (MLL) | Up to 10 years |
Secondary
| Measure | Time frame |
|---|---|
| predictive value of partial tandem duplication of ALL1 | Up to 10 years |
Countries
United States
Outcome results
None listed