Irinotecan in Treating Patients With Colorectal Cancer

UGT1A1 Polymorphism in Patients With Colorectal Cancer Treated With CPT-11 (Irinotecan)

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00003843

Enrollment

Registered

2003-01-27

Start date

1998-10-31

Completion date

2001-02-28

Last updated

2015-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

stage IV colon cancer, stage IV rectal cancer, recurrent colon cancer, recurrent rectal cancer

Brief summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of irinotecan in treating patients who have colorectal cancer.

Detailed description

OBJECTIVES: * Determine the frequency of genetic polymorphisms of UGT1 in Hispanics with colorectal cancer. * Determine if pharmacokinetics of irinotecan and its metabolites, SN38 and SN38G, are associated with the genotype of UGT1 and clinical toxicity. * Determine whether the genetic polymorphisms of UGT1 are associated with clinical toxicity and pharmacokinetics/pharmacodynamics of irinotecan in patients with unresectable colorectal cancer treated with irinotecan. * Determine the response, time to progression, and survival in patients with UGT1A1 polymorphisms treated with irinotecan. OUTLINE: Genomic DNA is isolated from blood samples from patients and analyzed for UGT1 polymorphisms. Patients are stratified according to UGT1 genotype (homozygous for wild type vs heterozygous for abnormal allele vs homozygous for abnormal allele). Patients receive irinotecan over 90 minutes weekly for 4 weeks. Treatment repeats every 6 weeks in the absence of disease progression or unacceptable toxicity. PROJECTED ACCRUAL: Approximately 28 patients will be accrued for this study.

Interventions

DRUGirinotecan hydrochloride

GENETICmutation analysis

GENETICpolymorphism analysis

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

DISEASE CHARACTERISTICS: * Histologically proven advanced or disseminated colorectal cancer * Progressive disease on fluorouracil based chemotherapy OR * Recurrence of disease within 12 months of adjuvant therapy with fluorouracil * No known CNS metastases or carcinomatous meningitis PATIENT CHARACTERISTICS: Age: * 18 and over Performance status: * SWOG 0-2 Life expectancy: * At least 12 weeks Hematopoietic: * Granulocyte count greater than 1500/mm\^3 * Platelet count greater than 100,000/mm\^3 * Hemoglobin at least 9.0 g/dL Hepatic: * Bilirubin no greater than 2 times upper limit of normal (ULN) * SGOT no greater than 3 times ULN (no greater than 5 times ULN if liver involved) Renal: * Creatinine no greater than 2.0 mg/dL * Calcium no greater than 12.0 mg/dL Cardiovascular: * No myocardial infarction within past 6 months * No congestive heart failure requiring therapy Neurologic: * No severe psychiatric disorders * No history of seizures Other: * No active or uncontrolled infection * HIV negative * No prior malignancy within past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix * No uncontrolled diabetes mellitus (random blood sugar 200 mg/dL or greater) * No other severe concurrent disease * Not pregnant or nursing * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * See Disease Characteristics * Prior oxaliplatin allowed * No prior irinotecan or topotecan Endocrine therapy: * Not specified Radiotherapy: * Not specified Surgery: * Not specified Other: * No concurrent phenytoin, phenobarbital, or other antiepileptic prophylaxis

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026