Colorectal Cancer
Conditions
Keywords
stage II colon cancer, stage III colon cancer, adenocarcinoma of the colon
Brief summary
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer. PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
Detailed description
OBJECTIVES: * Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer. * Determine if patient prognosis is dependent on the region of 8p AI. * Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p. * Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI. OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.
Interventions
GENETICDNA stability analysis
GENETICgene mapping
Sponsors
National Cancer Institute (NCI)
NCIC Clinical Trials Group
Alliance for Clinical Trials in Oncology
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 69 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosis of resectable stage II or III adenocarcinoma of the colon * Participated in NCCTG-914653 * DNA extracted from both normal and tumor tissue PATIENT CHARACTERISTICS: Age * Under 70
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival | Up to 10 years |
Countries
Canada, United States
Outcome results
None listed