Colorectal Cancer
Conditions
Keywords
stage III colon cancer, adenocarcinoma of the colon
Brief summary
RATIONALE: Analyzing the structure of genes found in a person's cancer cells may help doctors improve methods of treating patients with colon cancer. PURPOSE: Clinical trial to study the genes of patients treated with chemotherapy for colon cancer.
Detailed description
OBJECTIVES: * Determine the relationship between disease free survival, overall survival, and tumor replication error status for patients who have received adjuvant chemotherapy for colon cancer on CALGB protocol 8896. * Determine the prognostic and predictive values for response to this therapy in these patients.
Interventions
GENETICmutation analysis
Sponsors
National Cancer Institute (NCI)
Alliance for Clinical Trials in Oncology
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Patients who received chemotherapy for colon cancer as part of CALGB protocol 8896 * Underwent an initial resection for adenocarcinoma of the colon and were determined to have a high risk of tumor recurrence based upon nodal disease or local extension of tumor with obstruction or perforation due to tumor * Surgical specimen blocks available, including tumor tissue and normal tissue
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disease free survival | Up to 10 years |
Secondary
| Measure | Time frame |
|---|---|
| overall survival | Up to 10 years |
| tumor replication error status | Up to 10 years |
| determine the prognostic and predictive values for response to this therapy | Up to 10 years |
Countries
United States
Outcome results
None listed