FindTrial
Sign In

The Effects of AZT and Ibuprofen on HIV-Infected Patients With Hemophilia

Study of Bleeding Tendency, Platelet Function, and Pharmacokinetics of Azidothymidine (AZT) and Motrin (Ibuprofen) in HIV-Infected Hemophiliacs

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00002276
Enrollment
Unknown
Registered
2001-08-31
Start date
Unknown
Completion date
Unknown
Last updated
2005-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemophilia A, HIV Infections

Keywords

Blood Platelets, Ibuprofen, Drug Interactions, Zidovudine, Hemophilia A

Brief summary

To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.

Interventions

DRUGIbuprofen
DRUGZidovudine

Sponsors

University of Pittsburgh
Lead SponsorOTHER

Study design

Primary purpose
TREATMENT

Eligibility

Sex/Gender
ALL
Age
12 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients must have: * Hemophilia. * HIV-seropositivity confirmed by Western Blot. Prior Medication: Required: \- AZT for study patients. Allowed: \- Ibuprofen.

Exclusion criteria

Co-existing Condition: Patients with the following symptoms and conditions are excluded: Hospitalization for opportunistic infection, bacterial infection or malignancy. Concurrent Medication: Excluded: * AZT (for control group). * Antibiotics or other medication for opportunistic infection, bacterial infection, or malignancy. Patients with the following prior conditions are excluded: Hospitalization for opportunistic infection, bacterial infection, or malignancy. Required: * Ibuprofen. * AZT 1-2 gm daily (for study patient) or not taking AZT (for control).

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026