HIV Infections
Conditions
Keywords
Weight Loss, Parenteral Nutrition, Total, AIDS-Related Opportunistic Infections, Liposyn, Acquired Immunodeficiency Syndrome
Brief summary
To compare two lipid emulsions in the long-term parenteral alimentation of patients with AIDS in relation to: Clinical effectiveness. Effect on immunologic function. Effect on HIV load as measured by p24 antigen levels. Effect on relative HIV infectivity.
Interventions
DRUGFat Emulsion 2%
DRUGFat Emulsion 20%
Sponsors
Abbott
Study design
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Concurrent Medication: Allowed: * Zidovudine (AZT). * All drugs used for the standard treatment of opportunistic infections. * Other drugs used for the treatment of other AIDS conditions if they have been started more than 3 months prior to study entry. Patients must have: * Diagnosis of AIDS. * Weight loss of \> 10 percent premorbid body weight. * Presenting diagnosis of either opportunistic infection or Kaposi's sarcoma. * Require home total parenteral nutrition (TPN) for a period of approximately 3 months. * Life expectancy = or \> 90 days. Prior Medication: Allowed: * Zidovudine (AZT).
Exclusion criteria
Co-existing Condition: Patients with the following conditions or symptoms are excluded: * Life expectancy \< 90 days. * Biliary stasis. * History of drug abuse. Patients with the following are excluded: * Life expectancy \< 90 days. * Biliary stasis. * History of drug abuse. Prior Medication: Excluded within 3 months of study entry: * Immunomodulators. * Experimental antiviral DT. History of drug abuse.
Countries
United States
Outcome results
None listed