Studies of Blood Flow to the Brain During Thought

Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00001360

Enrollment

4100

Registered

1999-11-04

Start date

1993-09-17

Completion date

Unknown

Last updated

2026-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteer

Keywords

Cognition, Vision, Cortex, Visual Processing, Magnetic Resonance Imaging, Natural History

Brief summary

The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks. This study will use functional magnetic resonance imaging (fMRI) to examine blood flow to areas of the brain as participants engage in tasks associated with visual perception, visual recognition, and memory.

Detailed description

Objective: Our goal is to study the functional organization of the intact human brain by combining cognitive tasks and neuroimaging. Functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG) and electroencephalography (EEG) will be used to measure brain activity in healthy human subjects engaged in performing cognitive tasks. These tasks will address specific questions concerning the neural systems that mediate perception, attention, memory, decision-making, emotion, plasticity and social interactions. fMRI and MEG, respectively, will be employed to investigate the spatial and temporal aspects of these neural systems. Study Population: Normal volunteer participants aged 18-65, who are in good general health will be recruited from the local community and studied under this minimal risk protocol. Design: Subjects will perform cognitive tasks in behavioral and/or neuroimaging sessions (fMRI or MEG). Outcome Measures: Behavior as performance on cognitive tasks, and brain activity (fMRI and MEG) will be combined to yield information about the neural correlates and processes underlying different aspects of human cognition including visual perception, memory, learning, emotion, social cognition, decision-making and attention.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* INCLUSION CRITERIA: * Healthy adults, with at least a high school education, aged 18 to 65 years, will be recruited to participate in the study. * Able to read and write in English to guarantee understanding of all written and spoken instructions, which are in English.

Exclusion criteria

Subjects will be excluded if they: * have evidence of, or a history of: * major medical, neurological or psychiatric illness * serious head injury * learning disability-drug or alcohol abuse or dependence in the past 3 months, except nicotine -are taking prescription drugs or supplements that may affect brain function- -have serious vision or hearing problems In addition to the above, additional

Design outcomes

Primary

Measure	Time frame	Description
Cognitive tasks and neuroimaging.	ongoing	Cognitive tasks and neuroimaging.

Countries

United States

Contacts

CONTACTNIMH LBC Volunteer

nimhlbcvolunteer@mail.nih.gov(301) 827-5157

CONTACTChristopher I Baker, Ph.D.

bakerchris@mail.nih.gov(301) 435-6058

PRINCIPAL_INVESTIGATORChristopher I Baker, Ph.D.

National Institute of Mental Health (NIMH)

Outcome results