Diagnosing and Treating Low Blood Sugar Levels

Fasting Hypoglycemia: Diagnosis and Treatment

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00001276

Enrollment

1500

Registered

1999-11-04

Start date

1991-05-21

Completion date

Unknown

Last updated

2026-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypoglycemia, Insulinoma

Keywords

Hypoglycemia, Insulinoma, Natural History

Brief summary

Hypoglycemia is the term used to refer to lower than normal levels of blood sugar. This study will continue to research the causes of hypoglycemia. Patients involved in the study will be admitted to the Clinical Center of the National Institutes of Health and undergo tests for evaluating blood sugar. Patients will be required to refrain from eating for a set period of time and will undergo blood tests for insulin levels and several other specific diagnostic tests related to insulin secretion. The patients will be under supervision and will be provided with appropriate medical and surgical attention as needed.

Detailed description

Study Description: The purpose of this study is to gain knowledge and experience in the diagnosis and therapy of patients with fasting hypoglycemia due to diverse etiologies, such as insulinomas. Study subjects will be evaluated and treated for their particular condition according to standard care. Objectives: 1. To understand the pathophysiology and various causes of hypoglycemia (e.g., insulinomas, MEN1, MEN2). 2. To identify new circulating biomarkers of insulinomas. 3. To create a repository of clinical data and samples for future research of insulinomas. Endpoints: None

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 120 Years

Healthy volunteers

Inclusion criteria

* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Male, females ages \>= 18. 2. Patients with documented fasting blood glucose below 55 mg/dl. 4\. Patients with biochemical evidence for insulinoma or other pancreatic neuroendocrine tumors.

Exclusion criteria

An individual who meets any of the following criteria will be excluded from participation in this study: 1. Patients with significant cardiac disease will be excluded. 2. Subjects who are pregnant per self-report. 3. Medically unstable per the assessment of the PI.

Design outcomes

Primary

Measure	Time frame	Description
Treatment Outcomes	every 1-3 months	resolution of hypoglycemia

Countries

United States

Contacts

CONTACTCraig S Cochran, R.N.

craigc@bdg10.niddk.nih.gov(301) 402-1880

CONTACTRanganath Muniyappa, M.D.

muniyapr@mail.nih.gov(301) 451-7702

PRINCIPAL_INVESTIGATORRanganath Muniyappa, M.D.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Outcome results