Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

Regional Cerebral Utilization of Glucose in Patients With a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00001178

Enrollment

597

Registered

1999-11-04

Start date

1981-01-19

Completion date

2012-12-17

Last updated

2019-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease, Dementia, Down's Syndrome

Keywords

Alzheimer's Disease, Cerebral Metabolism, Cerebrospinal Fluid, Dementia of the Alzheimer Type, 18-F-Fluoro-2-Deoxy-D-Glucose (FDG), Magnetic Resonance Imaging, Positron Emission Tomography, X-Ray Computed Tomography (CT), Senile Dementia, Down Syndrome, Trisomy 21

Brief summary

The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.

Detailed description

Objective To continue the cross-sectional and longitudinal studies performed by the Cognitive Neuroscience Section of NINDS on the neuroanatomy, cerebral metabolism, neuropsychology, and genetics of frontotemporal dementia, corticobasal syndrome, and related brain disorders. Study population Frontal lobe dementias and atypical basal ganglia disorders including frontotemporal dementia, corticobasal syndrome, and related brain disorders. Design A cross-sectional assessment of neuropsychological, brain anatomical and metabolic function, and genetic measures in subjects with these disorders. Outcome measures MRI, FDG-PET, neuropsychological and clinical tests, genetics, and neuropathology.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Subjects will be recruited from the NIH referral center, neurological and psychiatric clinics, from self or family referral in response to advertisements or from private physicians. Healthy volunteers will include subjects who are considered at-risk for the development of FTD or CBS and subjects who serve as normal controls matched for key characteristics with the patients. INCLUSION CRITERIA FOR PATIENTS: * Diagnosis of possible / probable FTD or CBS * Caregiver willing and able to accept the responsibilities involved in the study

Exclusion criteria

* Pregnant women. Women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test. These women will be excluded from the imaging portions of the protocol. * Behavioral symptoms that would preclude the gathering of data for the study * Other medical or social condition that would preclude participation in the opinion of the investigators

Countries

United States

Outcome results