Clinical Investigation of Infections Due to Leishmanial Parasites

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00001169

Enrollment

250

Registered

2002-12-10

Start date

1979-12-31

Completion date

2001-02-28

Last updated

2008-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Leishmaniasis, Leishmaniasis, Visceral

Keywords

Chemotherapy, Cytokines, Immunology, Kala-Azar, Leishmaniasis

Brief summary

Mechanisms of host immune response to intracellular protozoa will be investigated in patients with naturally acquired infection employing a variety of in-vitro techniques. Both non-specific and antigen-specific humoral and cellular immune responses will be assessed. Parasites will be isolated from patients, cultivated in-vitro, and characterized. Responses to chemotherapy will be assessed parasitologically, immunologically and clinically.

Detailed description

The main purpose of this protocol is to permit us to see patients who are referred to us for diagnosis and treatment of known or suspected leishmaniasis (from the Peace Corps, Smithsonian Institution, tourists, etc.). In the process of working up these patients, we sometimes encounter parasite isolates that are useful for research. We also can perform tests of cell-mediated immune function to evaluate how patients are responding to therapy. In addition, the protocol permits us to observe therapeutic responses to other drugs besides pentavalent antimony, if necessary.

Interventions

None listed

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

Must be between the ages of 1 and 65 years.

Countries

United States

Outcome results