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Pemoline in the Treatment of Stimulant Dependence - 5

Pemoline in the Treatment of Stimulant Dependence

Status
Withdrawn
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00000340
Enrollment
0
Registered
1999-09-21
Start date
1996-06-30
Completion date
Unknown
Last updated
2017-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cocaine-Related Disorders

Keywords

cocaine dependence

Brief summary

The purpose of this study is to assess the efficacy of pemoline in treating cocaine and/or methamphetamine dependent adults with comorbid Adult Attention Deficit Hyperactivity Disorder (ADHD).

Interventions

DRUGPemoline

Sponsors

National Institute on Drug Abuse (NIDA)
Lead SponsorNIH

Study design

Primary purpose
TREATMENT

Eligibility

Sex/Gender
ALL
Age
21 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.

Exclusion criteria

Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.

Design outcomes

Primary

MeasureTime frame
Retention—
Depression—
Incidence of stimulant use—
Severity of stimulant withdrawal symptoms—
ADHD symptom severity—
Degree of drug craving—
Frequency of IV drug use and sexual risk behaviors—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026