Cocaine-Related Disorders
Conditions
Keywords
cocaine dependence
Brief summary
The purpose of this study is to evaluate clinical safety issues pertaining to risperidone, to cocaine and to its interaction, and to determine how pretreatment with risperidone modifies the subjective as well as physiological effects of cocaine.
Interventions
DRUGRisperidone
Sponsors
National Institute on Drug Abuse (NIDA)
Study design
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
21 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.
Exclusion criteria
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency and intensity of drug use and sexual beh | — |
| Evidence of change in neurotoxicity based on chore | — |
| Degree of drug craving | — |
| History, incidence and amount of drug use | — |
| Type and severity of stimulant withdrawal symptoms | — |
| Characterization of study population | — |
| Population incidence of symptoms of depression, po | — |
| Evidence of change in subjective responses to coca | — |
| Clinical physiological response to cocaine challen | — |
| Degree to which study medication influences change | — |
Countries
United States
Outcome results
None listed