Cocaine-Related Disorders
Conditions
Keywords
cocaine dependence
Brief summary
The purpose of this study is to determine the effects of selegiline on the subjective and physiological effects of cocaine challenge in chronic crack abusers, and to evaluate clinical safety issues pertaining to selegeline, to cocaine and their interaction in a chronic crack dependent population.
Detailed description
To develop a medication for the treatment of cocaine addiction using a medical human physio-neuro-psycho-immunology laboratory setting. To characterize this cocaine abusing population on a variety of psychological and physicologically measures over time from withdrawal through pere and post cocaine administration. To determine the effects of selegeline on the subjective and physiological effects of cocaine challenge in chronic crack abusers. To evaluate clinical safety issues pertaining to selegeline, to cocaine and their interaction in a chronic crack dependent population.
Interventions
DRUGSelegiline
Sponsors
National Institute on Drug Abuse (NIDA)
Study design
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
31 Years to 47 Years
Healthy volunteers
No
Inclusion criteria
M/F, ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.
Exclusion criteria
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Population incidence of symptoms of depression, possible organic brain syndrome deficits | — |
| Frequency and intensity of drug use and sexual behaviors at risk for HIV | — |
| Evidence of change in neurophysiology and brain activity | — |
| Evidence of change in subjective responses to cocaine challenge | — |
| Degree of drug craving | — |
| History, incidence and amount of drug use | — |
| Type and severity of stimulant withdrawal symptoms | — |
| Clinical physiological response to cocaine challenge - especially adverse effects measures | — |
| Degree to which study medication influences changes in #6, 7 & 8 above (possible efficacy measure) | — |
| Characterization of study population | — |
Countries
United States
Outcome results
None listed