Heroin Dependence, Opioid-Related Disorders
Conditions
Keywords
Heroin Dependence
Brief summary
The purpose of this study is to assess the abuse liability and examine the reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in healthy, non-drug dependent volunteers.
Detailed description
not available at this time
Interventions
DRUGTest Drug
DRUGPlacebo Drug
Sponsors
National Institute on Drug Abuse (NIDA)
University of Colorado, Denver
Study design
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Individuals must be healthy, non-drug dependent volunteers, be at least 18 years of age, and have no prior history of drug or alcohol abuse or dependence. Subjects must have had some minimal experience with opioids (e.g. at least two prior exposures)
Exclusion criteria
Individuals with evidence of an active Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Axis I psychiatric disorder (e.g. psychosis, manic-depressive illness, organic psychiatric disorders), significant medical illness (e.g., liver or cardiovascular disease) or pregnant female subjects are excluded from study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Observed withdrawal rating | — |
| Pupil diameter | — |
| Drug effect characteristics | — |
Countries
United States
Outcome results
None listed