Heroin Dependence, Opioid-Related Disorders
Conditions
Keywords
drug dependence
Brief summary
The purpose of this study is to assess the abuse liability and examine the reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in buprenorphine-naloxone maintained volunteers
Detailed description
Ongoing study - results not available at this time
Interventions
DRUGOpioid-Related Disorders
Sponsors
National Institute on Drug Abuse (NIDA)
University of Colorado, Denver
Study design
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Individuals must be at least 18 yrs of age, currently opioid dependent and meet FDA criteria for narcotic maintenance treatment. Co-morbid substance abuse or dependence disorders may also be present. Individuals must be healthy despite drug dependency and have a history of IV opioid use.
Exclusion criteria
Individuals with evidence of anti active Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Axis I psychiatric disorder (e.g. psychosis, manic-depressive illness, organic psychiatric disorders), significant medical illness (e.g. liver or cardiovascular disease) or pregnant female subjects are excluded from study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective dose estimate | — |
| Observed withdrawal rating | — |
| Opioid agonist rating | — |
| Opioid antagonist rating | — |
| Pupil diameter | — |
| Analog rating scale for drug effects | — |
| Drug effect characteristics | — |
| Drug/Money Preferences | — |
Countries
United States
Outcome results
None listed