Serotonin/Dopamine Antagonism of Cocaine Effect: 2 - 2

Serotonin/Dopamine Antagonism of Cocaine Effect

Status

Terminated

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00000310

Enrollment

Registered

1999-09-21

Start date

1996-01-31

Completion date

1996-03-31

Last updated

2017-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cocaine-Related Disorders

Keywords

cocaine dependence

Brief summary

The purpose of this study is to evaluate use of risperidone with cocaine abusers. Study measures incorporate an appropriate integration of behavioral and neurobiological indices.

Detailed description

Risperidone in low doses is compared with placebo in a 6-week randomized trial. Subjects also receive supportive counseling. Outcome measure include rating of behavior, mood, drug abuse, global function, and urine toxicology.

Interventions

DRUGRisperidone

Study design

Allocation

RANDOMIZED

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

Cocaine abuse or dependence

Exclusion criteria

Dependence on other drugs. Major psychiatric illness

Design outcomes

Primary

Measure	Time frame
Urine toxicology for cocaine	—
Analog mood scales	—
POMS	—
EPS sx	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026