Opioid-Related Disorders, Substance-Related Disorders
Conditions
Keywords
nitrous oxide, sevoflurane, drug interaction, subjective effects, analgesia, healthy volunteers
Brief summary
The purpose of this study is to determine the effects of combined sevoflurane and nitrous oxide inhalation on mood, psychomotor performance, and the pain response in humans.
Interventions
Sponsors
National Institute on Drug Abuse (NIDA)
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Please contact site for information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity, pain bothersomeness | During inhalation | Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4 |
| Mood | During inhalation | Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4 |
| Psychomotor performance | During inhalation | Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4 |
Countries
United States
Outcome results
None listed