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Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13

Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00000261
Enrollment
14
Registered
1999-09-21
Start date
1997-11-30
Completion date
1998-10-31
Last updated
2015-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders

Keywords

nitrous oxide, sevoflurane, ethanol, subjective effects, healthy volunteer

Brief summary

The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers. All subjects underwent psychomotor testing during 4 sessions of placebo, drug/placebo, and choice of intervention.

Interventions

DRUG30% Nitrous oxide
OTHERPlacebo

No drug (100% oxygen)

DRUG0.2% sevoflurane
DRUG0.4% sevoflurane
DRUG0.6% sevoflurane

Sponsors

National Institute on Drug Abuse (NIDA)
CollaboratorNIH
University of Chicago
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

Please contact site for information.

Design outcomes

Primary

MeasureTime frame
MoodBaseline, inhalation, recovery
Psychomotor performanceBaseline, inhalation, recovery
Choice of drug vs placeboAfter placebo and drug in each session

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026