Opioid-Related Disorders, Substance-Related Disorders
Conditions
Keywords
sevoflurane, nitrous oxide, subjective effects, healthy volunteer
Brief summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.
Interventions
Sponsors
National Institute on Drug Abuse (NIDA)
University of Chicago
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
Please contact site for information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity | 30 min of inhalation | Subjects underwent a 3 min cold immersion test at 30 min of inhalation and then provided response to pain intensity questionnaire |
| Psychomotor performance | Baseline, 5 min of inhalation; 5, 30, 60 minutes recovery | Subjects underwent psychomotor testing at baseline, during inhalation, and during recovery post inhalation |
| Cognitive performance | Baseline, every 5 min during inhalation, 5, 30, & 60 min during recovery | Subject underwent memory, sedation, visual analog, and drug effects testing |
Countries
United States
Outcome results
None listed