Opioid-Related Disorders, Substance-Related Disorders
Conditions
Keywords
nitrous oxide, instruction, subjective effects, reinforcer, healthy volunteer
Brief summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate the role of instructions in nitrous oxide subjective effects and choice.
Interventions
DRUGNitrous oxide 10% & placebo
DRUGNitrous oxide 20% & placebo
DRUGNitrous oxide 30% & placebo
DRUGNitrous oxide 40% and placebo
Sponsors
National Institute on Drug Abuse (NIDA)
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 32 Years
Healthy volunteers
Yes
Inclusion criteria
Please contact site for information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Choice of nitrous oxide vs placebo | After 30 min inhalation of each | Subjects inhaled placebo and varying per centages of nitrous oxide in sampling pair, then chose for third inhalation. One group was told which of the gases they were inhaling during sampling and one group as well as the technician administering the inhalant was blinded. Psychomotor tests were done at each dose. |
Countries
United States
Outcome results
None listed