Alcohol-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
Conditions
Keywords
nitrous oxide, subjective effects, ethanol, healthy volunteer
Brief summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To determine effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.
Interventions
DRUG0% N2O and 10% N2O
DRUG0% N2O and 20% N2O
DRUG0% N2O and 30% N2O
DRUG0% N2O and 40% N2O
Sponsors
National Institute on Drug Abuse (NIDA)
University of Chicago
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 37 Years
Healthy volunteers
Yes
Inclusion criteria
Please contact site for information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Choice of nitrous oxide vs placebo | After 30 min inhalation each of N2O and placebo | Two subject groups (light drinkers vs moderate drinkers) were asked to inhale a given conc of N2O and inhale a placebo, then choose for a third inhalation. The subject & the technician administering the inhalant were blinded. Testing was done at each dose. |
Countries
United States
Outcome results
None listed