Opioid-Related Disorders, Substance-Related Disorders
Conditions
Keywords
isoflurane, general anesthetic, inhalant, subjective effects, healthy volunteer
Brief summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
Interventions
DRUG40% Nitrous oxide
Used as pain assay positive control
OTHERSham comparator
0% isoflurane in oxygen
DRUG0.2% isoflurane
DRUG0.4% isoflurane
DRUG0.6% isoflurane
Sponsors
National Institute on Drug Abuse (NIDA)
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
21 Years to 34 Years
Healthy volunteers
Yes
Inclusion criteria
Please contact site for information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain response | Post inhalation | Effects of inhaled isoflurane on pain from immersion of subject's arm in ice cold water. Nitrous oxide (40%) was used as a positive control to confirm sensitivity of the pain assay. |
Countries
United States
Outcome results
None listed