Opioid-Related Disorders, Substance-Related Disorders
Conditions
Keywords
nitrous oxide, acute tolerance, subjective effects, psychomotor, analgesia, healthy volunteer
Brief summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.
Sponsors
National Institute on Drug Abuse (NIDA)
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 29 Years
Healthy volunteers
Yes
Inclusion criteria
Please contact site for information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Psychomotor performance | During inhalation | Subjects will undergo psychomotor testing during 120 min inhalation session of each intervention |
| Cognitive performance | During inhalation | Subjects will under cognitive testing during 120 minute inhalation session of each intervention |
Countries
United States
Outcome results
None listed