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Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3

Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00000251
Enrollment
10
Registered
1999-09-21
Start date
1994-04-30
Completion date
1996-01-31
Last updated
2015-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid-Related Disorders, Substance-Related Disorders

Keywords

nitrous oxide, isoflurane, subjective effects, psychomotor, healthy volunteer, drug interaction

Brief summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.

Interventions

DRUG30% N2O
DRUG0.2% isoflurane
DRUG0.4% isoflurane
OTHER100% oxygen

Placebo

Sponsors

National Institute on Drug Abuse (NIDA)
CollaboratorNIH
University of Chicago
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
21 Years to 32 Years
Healthy volunteers
Yes

Inclusion criteria

Please contact site for information.

Design outcomes

Primary

MeasureTime frame
Logical reasoning test15 & 30 min inhalation and 5, 30, & 60 min post inhalation
Free recall memory test15 & 30 min inhalation and 5, 30, & 60 min post inhalation
Auditory reaction time15 & 30 min inhalation and 5,30 & 60 min post inhalation
Digit symbol substitution test2,15 & 30 min inhalation and 5,30 & 60 min post inhalation

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026