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Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2

Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00000250
Enrollment
12
Registered
1999-09-21
Start date
1993-12-31
Completion date
1995-05-31
Last updated
2015-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid-Related Disorders, Substance-Related Disorders

Keywords

nitrous oxide, choice, subjective effects, pain, analgesia, reinforcer, healthy volunteer

Brief summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate: cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers.

Interventions

DRUG0% N2O

Subjects will inhale 100% oxygen with no N2O for 25 min then immerse forearm in warm water and cold water

DRUG40% N2O

Subjects will inhale 40% N2O then immerse forearm in warm water and cold water

Sponsors

National Institute on Drug Abuse (NIDA)
CollaboratorNIH
University of Chicago
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
21 Years to 32 Years
Healthy volunteers
Yes

Inclusion criteria

Please contact site for information.

Design outcomes

Primary

MeasureTime frame
Subject's choice of interventionAfter sampling trials

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026