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Effects of Subanesthetic Concentrations of Nitrous Oxide - 1

Effects of Subanesthetic Concentrations of Nitrous Oxide

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00000249
Enrollment
10
Registered
1999-09-21
Start date
1993-09-30
Completion date
1995-06-30
Last updated
2015-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid-Related Disorders, Substance-Related Disorders

Keywords

nitrous oxide, subjective effects, healthy volunteer

Brief summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.

Interventions

DRUG20% N2O

20% inhaled N2O

DRUG30% N2O

30% inhaled N2O

DRUG40% N2O

40% inhaled N2O

Sponsors

National Institute on Drug Abuse (NIDA)
CollaboratorNIH
University of Chicago
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
21 Years to 37 Years
Healthy volunteers
Yes

Inclusion criteria

Please contact site for information.

Design outcomes

Primary

MeasureTime frameDescription
Pain intensityduring cold test at 10 min & 30 min of inhalationSubjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026