FindTrial
Sign In

Effects of Dynorphin 1-13 on Heroin Addiction - 1

Effects of Dynorphin 1-13 on Heroin Addiction

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00000244
Enrollment
0
Registered
1999-09-21
Start date
1994-08-31
Completion date
1997-03-31
Last updated
2015-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid-Related Disorders, Substance Withdrawal Syndrome

Keywords

addiction, opiate, heroin, dynorphin

Brief summary

The purpose of this study is to evaluate the effects of IV dynorphin in humans during acute heroin abstinence, in order to determine that dynorphin suppresses acute opiate withdrawal, reduces opiate craving, and is safe at doses required to produce the above effects.

Detailed description

Randomized double blinded study of the effects of a single IV dose of dynorphin A 1-13 on heroin withdrawal in human opiate addicts

Interventions

DRUGDynorphin 1 - 13

Sponsors

National Institute on Drug Abuse (NIDA)
CollaboratorNIH
University of Minnesota
Lead SponsorOTHER

Study design

Primary purpose
TREATMENT
Masking
DOUBLE

Eligibility

Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No

Inclusion criteria

opiate addict between the ages of 18-55

Exclusion criteria

Regular abuse of other drugs, unstable medical conditions

Design outcomes

Primary

MeasureTime frame
Craving scale—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026