Opioid-Related Disorders
Conditions
Keywords
Opioid
Brief summary
The purpose of this study is to detect increasing medication dose results in heroin cessation for patients still using, to determine if decreasing medication dose in patients unable to tolerate medication dose increases retention, and to determine if blood levels of methadone or buprenorphine correlate with clinical response.
Interventions
DRUGBuprenorphine
Sponsors
National Institute on Drug Abuse (NIDA)
University of California, Los Angeles
Study design
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
21 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
M/F ages 21-50. Opiate dependence according to DSM-IV criteria. Self-reported use within the last 30 days. Agreeable to conditions of study and signed informed consent.
Exclusion criteria
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative-hynotics. Acute hepatitis. Other medical conditions that deem participation to be unsafe.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Retention | — |
| Opiate use | — |
| Opiate craving | — |
| Adverse events | — |
Countries
United States
Outcome results
None listed