Alzheimer's Disease Prevention Trial

Alzheimer's Disease Prevention Trial. A Multi-center, Randomized, Double-blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00000176

Enrollment

Unknown

Registered

1999-11-01

Start date

Unknown

Completion date

2007-09-30

Last updated

2010-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease, Memory Disorders

Keywords

Alzheimer's disease, memory loss, Estrogen

Brief summary

This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.

Detailed description

PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

Interventions

DRUGEstrogen

DRUGEstrogen and Progesterone

Study design

Allocation

RANDOMIZED

Primary purpose

PREVENTION

Masking

DOUBLE

Eligibility

Sex/Gender

FEMALE

Age

65 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy women 65 or older with a family history of memory problems not currently on estrogen.

Exclusion criteria

* Significant neurological impairment * Current estrogen use * History of breast cancer

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026