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Efficacy of levocetirizine IN reducing Double J stent-related symptoms: A double-blind pilot randomized controlled trial

Efficacy of levocetirizine IN reducing Double J stent-related symptoms: A double-blind pilot randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
LBCTR
Registry ID
LBCTR2025105754
Enrollment
60
Registered
2025-10-29
Start date
2025-03-01
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive ureteral disease requiring temporary urinary drainage with a double-J ureteral stent Associated double-J stent–related lower urinary tract symptoms (dysuria, frequency, urgency, flank pain) and stent-related discomfort lithiasis, double J stent

Interventions

Group B (Experimental Group): Levocetirizine (XYZAL) 5 mg oral tablet once daily Administration starts at least 2 hours pre-operatively and continues daily until stent removal (maximum 3 weeks) Giv
placement of double J + giving either xyal 5mg daily or olacebo than double j removal and evaluationg irritating symptoms
double J stent, lithiasis, antihistamin

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Adults aged 18 years or older. Patients who underwent double J ureteral stent placement for obstructive ureteral disease at CHU-NDS. Patients who are able and willing to provide written informed consent. Patients capable of complying with study procedures and follow-up requirements.

Exclusion criteria

Exclusion criteria: Exclusion criteria: Radiation-induced ureteritis Pregnancy or breastfeading Malignancy or extrinsic ureter obstruction Known allergy or CI to the study drugs Previous ureteral stenting Patient taking anti-allergic in the previous month Refusal to provide consent

Design outcomes

Secondary

MeasureTime frame
Name: VAS;Timepoints: upon ureteroscopy;Measure: visual analogue pain scale

Primary

MeasureTime frame
Name: Ureteral inflammation ;Timepoints: uponureteroscopy;Measure: macroscopically (inflammed or no);Name: double J stent;Timepoints: upon ureteroscopy;Measure: calcified or no;Name: USSQ;Timepoints: after ureteroscopy;Measure: ureteral stent symptoms questionnaire

Countries

Lebanon

Contacts

Public Contactrodrigue saad

supervisor

rodriguesaad@usek.edu.lb71240014

Outcome results

None listed

Source: LBCTR (via WHO ICTRP) · Data processed: Feb 7, 2026