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Comparison of Two Treatment Regimens for Helicobacter pylori Eradication in Lebanon

A Randomized Prospective and Crossover Study Comparing the Eradication Rate After 10 Days of Concomitant Therapy to Bismuth Quadruple Therapy Among a Sample of the Lebanese Population - RCT-COMP-BQT

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
LBCTR
Registry ID
LBCTR2024095653
Enrollment
427
Registered
2024-10-17
Start date
2016-03-01
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The health condition/problem studied in this trial is **Helicobacter pylori infection**, which is associated with gastrointestinal disorders such as gastritis, peptic ulcers, and an increased risk of gastric cancer and MALT lymphoma.

Interventions

The interventions in the study were two treatment regimens for the eradication of *Helicobacter pylori*: 1. **Concomitant Therapy**: A 10-day regimen consisting of esomeprazole 40 mg twice daily, amo

Sponsors

Holy Spirit University of Kaslik (USEK), School of Medicine and Medical Sciences.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria for the study were: 1. **Positive Helicobacter pylori infection** confirmed through histological findings. 2. **No prior eradication therapy** for *Helicobacter pylori*. 3. **Written informed consent** provided by all participants. These criteria ensured that the study focused on patients with active *H. pylori* infections who had not undergone previous treatment.

Exclusion criteria

Exclusion criteria: The exclusion criteria for the study were as follows: 1. **Recent exposure to antibiotics**. 2. **History of allergy or intolerance** to any of the components in the treatment regimens. 3. **Presence of gastric cancer** confirmed by histological findings. 4. **Patients who had undergone prior eradication therapy** for *Helicobacter pylori*. These criteria ensured the exclusion of patients who might have confounding factors affecting treatment outcomes or safety.

Countries

Lebanon

Contacts

Public ContactJad Chidiac

USEK

jad_chidiac@live.com0763918897

Outcome results

None listed

Source: LBCTR (via WHO ICTRP) · Data processed: Feb 7, 2026