None listed
Conditions
Interventions
Procedure/Surgery : With the participant seated comfortably and fitted with transcranial Doppler (TCD) and Finapres, a single 30-second breath-hold Valsalva maneuver was performed on cue after a 10-mi
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults aged 20–60 years 2. No history of traumatic brain injury, brain tumor, stroke, epilepsy, neuroinflammatory disease, metabolic encephalopathy, neurodegenerative disease, or cardiovascular disease 3. Not taking medications affecting autonomic responses (e.g., sympathomimetics, anticholinergics) 4. Provided voluntary written informed consent
Exclusion criteria
Exclusion criteria: 1. Inadequate transtemporal acoustic window precluding transcranial doppler signal acquisition 2. Inability to maintain measurements 3. Occurrence of adverse events during the Valsalva test (vasovagal syncope, arrhythmia, or chest pain)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation coefficients between VMOI and conventional cerebral autoregulation (CA) indices: mean flow index, systolic flow index, diastolic flow index, transfer function analysis gain/phase (very low and low frequency bands), autoregulation index, Valsalva maneuver autoregulatory index, and autoregulation slope index | — |
Secondary
| Measure | Time frame |
|---|---|
| Association between VMOI and conventional CA indices after adjustment for demographic characteristics (multivariable linear regression) | — |
Countries
Korea, Republic of
Contacts
Public ContactJehun Jang
Seoul National University Bundang Hospital
Outcome results
None listed