Effects of Food Intake and Bowel Preparation on Exhaled Volatile Organic Compounds in Healthy Adults

Conditioning study for exhaled volatile organic compounds (VOCs) as a diagnostic marker for colorectal cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0012344

Enrollment

Registered

2026-07-28

Start date

2024-08-19

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Behavioral : This was a prospective interventional study conducted to evaluate the effects of dietary intake and bowel preparation on exhaled volatile organic compounds (VOCs) in healthy adults. The s

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults aged 19 years or older. Individuals with no clinically significant colorectal disease confirmed by a colonoscopy performing within the previous 2 years, or individuals considered healthy based on the investigator's medical evaluation. Individuals considered generally healthy based on medical history, medication history, physical examination, and vital signs, and deemed eligible by the investigator. Individuals who voluntarily provided written informed consent after receiving a full explanation of the study. Individuals able to comply with the study procedures, including dietary intervention or bowel preparation and serial exhaled breath sample collection.

Exclusion criteria

Exclusion criteria: Individuals with asthma or severe chronic obstructive pulmonary disease. Individuals with uncontrolled diabetes mellitus (HbA1c =7.0% or diabetic ketoacidosis). Individuals with chronic inflammatory diseases, including Crohn's disease or ulcerative colitis. Individuals who underwent bowel preparation or colonoscopy within 1 week before enrollment. Individuals with a history of infectious disease (e.g., pneumonia, hepatitis, urinary tract infection) or acute cardiac, neurologic, or renal disease within 2 weeks before enrollment. Pregnant or breastfeeding women, or women with the potential for pregnancy. Individuals with confirmed congenital diseases. Individuals with a history of major gastrointestinal surgery. Individuals who participated in another clinical study within 30 days before enrollment. Individuals considered unsuitable for study participation by the investigator.

Design outcomes

Primary

Measure	Time frame
Changes in the absolute concentrations of candidate exhaled volatile organic compounds for colorectal cancer before and after dietary intake, and bowel preparation	—

Secondary

Measure	Time frame
Changes in baseline-normalized relative concentrations of candidate exhaled volatile organic compounds for colorectal cancer before and after dietary intake, and bowel preparation	—

Countries

Korea, Republic of

Contacts

Public ContactSe-Jin Baek

Korea University

xezin79@gmail.com+82-2-920-6412

Outcome results